Target-specific application of cellular therapy
Pilot tests will be carried out to validate a method that allows cells to be applied into the sphincter muscle whilst causing as little damage to the tissue as possible. The method will be developed and optimised in a demonstrating unit and subsequently tested in explants and animal models prior to its clinical application. Using an endoscopic approach, the dosing unit allows a non-invasive application of cells; a navigation system supports the precise localisation of the cells. Positioned at the sphincter with the help of a synchronised rectal ultrasound probe and an endoscopic image, the endoscope allows the surgeons to apply the cells into the muscle using microtechnological tools. The navigation system is used to position and direct the dosing device.
A demonstrating unit will be developed to design the planned animal experiments and assess the two issues of “non-invasive dosing” and “precise application”. The demonstrating unit will be designed in a way that enables the surgeon to bring the needles and nozzles directly to the tissue samples and test the navigation functions. The method will be validated with tissue and organ explants and optimised for clinical application in humans using large animal models.
Prof. Dr. med. Arnulf Stenzl
Department of Urology, Tübingen University Hospital
Dr. ing. Jan Stallkamp
Department of Production and Process Automation
Head of department
Project team members
Dr. med. Luis Arenas da Silva
Department of Urology
Holder of DFG - Gerok position
Dr. rer. nat. Andrea Traube
Fraunhofer IPA Stuttgart